MHC class II gene silencing in trophoblast cells is caused by inhibition of CIITA expression.
| Author | |
|---|---|
| Abstract | :
Major histocompatibility complex (MHC) class II molecule expression is specifically suppressed on fetal trophoblasts, even in response to interferon (IFN)-gamma, a potent inducer of MHC class II genes. The suppression of class II induction has been suggested to play a role in preventing rejection of the fetal allograft. The mechanism of this suppression is unknown. |
| Year of Publication | :
1998
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| Journal | :
American journal of reproductive immunology (New York, N.Y. : 1989)
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| Volume | :
40
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| Issue | :
6
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| Number of Pages | :
385-94
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| ISSN Number | :
1046-7408
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| URL | :
https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1046-7408&date=1998&volume=40&issue=6&spage=385
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| DOI | :
10.1111/j.1600-0897.1998.tb00423.x
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| Short Title | :
Am J Reprod Immunol
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