Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma.
| Author | |
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| Abstract | :
Current intra-arterial chemotherapy (IAC) drug regimens for retinoblastoma have ocular and vascular toxicities. No small-animal model of IAC exists to test drug efficacy and toxicity in vivo for IAC drug discovery. The purpose of this study was to develop a small-animal model of IAC and to analyze the ocular tissue penetration, distribution, pharmacokinetics, and treatment efficacy. |
| Year of Publication | :
2018
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| Journal | :
Investigative ophthalmology & visual science
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| Volume | :
59
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| Issue | :
1
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| Number of Pages | :
446-454
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| Date Published | :
2018
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| ISSN Number | :
0146-0404
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| URL | :
http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.17-22302
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| DOI | :
10.1167/iovs.17-22302
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| Short Title | :
Invest Ophthalmol Vis Sci
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