Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias.
| Author | |
|---|---|
| Abstract | :
In human cardiac ventricle, IK1 is mainly comprised Kir2.1, but Kir2.2 and Kir2.3 heterotetramers occur and modulate IK1. Long-QT syndrome-9-associated CAV3 mutations cause decreased Kir2.1 current density, but Kir2.x heterotetramers have not been studied. Here, we determine the effect of long-QT syndrome-9-CAV3 mutation F97C on Kir2.x homo- and heterotetramers and model-associated arrhythmia mechanisms. |
| Year of Publication | :
2018
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| Journal | :
Circulation. Arrhythmia and electrophysiology
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| Volume | :
11
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| Issue | :
1
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| Number of Pages | :
e005800
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| ISSN Number | :
1941-3149
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| DOI | :
10.1161/CIRCEP.117.005800
|
| Short Title | :
Circ Arrhythm Electrophysiol
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