Dexmedetomidine reduces lipopolysaccharide induced neuroinflammation, sickness behavior, and anhedonia.
| Author | |
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| Abstract | :
Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect. We investigated the effects of Dex on lipopolysaccharide (LPS)-induced neuroinflammation and sickness behavior in mice. |
| Year of Publication | :
0
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| Journal | :
PloS one
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| Volume | :
13
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| Issue | :
1
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| Number of Pages | :
e0191070
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| Date Published | :
2018
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| URL | :
http://dx.plos.org/10.1371/journal.pone.0191070
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| DOI | :
10.1371/journal.pone.0191070
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| Short Title | :
PLoS One
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| Download citation |