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Kaplan-Meier Estimator, Alternative Variance Formula and Restricted Mean Survival Time Based Tests

Date:
Location:
https://uky.zoom.us/j/83021956044
Speaker(s) / Presenter(s):
Dr. Mai Zhou, University of Kentucky

Abstract: Recently there are many research reports that advocate the use of Restricted Mean Survival Time (RMST) to compare treatment effects when the Proportional Hazards assumption is in doubt (i.e. when the log-rank test may not work well). SAS STAT version 15.1 or later included this option.

 

We shall take a closer look at the variance of the Kaplan-Meier integral, both theoretically (as related to the Semiparametric Fisher Information) and how to estimate it (if we must).

 

Some simulation for proposed improvements over the existing RMST tests calculation will be presented.

 

Event Series: